In the majority of cultures and societies gender is strongly defined as male and female. Anyone that does not feel they fit in one of these definitions is presented with life problems. The social consequences of being gay, transgender, or anything else then is the standard have proven to be enormous. In most countries it means being socially excluded from education, work, health care and family life. To turn this around, a new definition is needed, that allows for diversity in society. Focus on single issues as only HIV / STD problems, rarely help to bring about the changes needed to resolve the social consequences.